1351978-48-7
1351978-48-7 structure
- Name: TLR9 inhibitor 18
- Chemical Name: TLR9 inhibitor 18
- CAS Number: 1351978-48-7
- Molecular Formula: C25H36N6O2
- Molecular Weight: 452.603
- Create Date: 2020-01-12 11:41:49
- Modify Date: 2024-01-11 16:44:19
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A potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM); inhibits CpG-induced IL-6 production in mouse spleen and human PBMCs with IC50 of 74 and 244 nM, respectively; inhibits CpG-induced IL-6 production with ED50 of 0.8 mg/kg in mice, has great potential in the treatment of TLR9-mediated systemic uncontrollable inflammatory response like sepsis.
| Name | TLR9 inhibitor 18 |
|---|
| Description | A potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM); inhibits CpG-induced IL-6 production in mouse spleen and human PBMCs with IC50 of 74 and 244 nM, respectively; inhibits CpG-induced IL-6 production with ED50 of 0.8 mg/kg in mice, has great potential in the treatment of TLR9-mediated systemic uncontrollable inflammatory response like sepsis. |
|---|---|
| References | References 1. Watanabe M, et al. ACS Med Chem Lett. 2014 Oct 2;5(11):1235-9. View Related Products by Target Toll-like Receptor (TLR) |
| Molecular Formula | C25H36N6O2 |
|---|---|
| Molecular Weight | 452.603 |