2230873-66-0
2230873-66-0 structure
- Name: KRAS inhibitor-18
- Chemical Name: KRAS inhibitor-18
- CAS Number: 2230873-66-0
- Molecular Formula: C20H15ClF3N3O2S
- Molecular Weight: 453.87
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2022-07-19 16:25:05
- Modify Date: 2024-01-02 19:12:13
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KRAS inhibitor-18 (compound 3-10) is a potent KRAS G12C inhibitor with an IC50 of 4.74 µM. KRAS inhibitor-18 shows p-ERK inhibition activities with IC50s of 66.4, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-18 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
| Name | KRAS inhibitor-18 |
|---|
| Description | KRAS inhibitor-18 (compound 3-10) is a potent KRAS G12C inhibitor with an IC50 of 4.74 µM. KRAS inhibitor-18 shows p-ERK inhibition activities with IC50s of 66.4, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-18 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
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| Related Catalog | |
| Target |
KRas G12C:4.74 μM (IC50) |
| References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
| Molecular Formula | C20H15ClF3N3O2S |
|---|---|
| Molecular Weight | 453.87 |