DC Chemicals Limited
China
Product Name: AZ3451
Price: $750.0/100mg $1400.0/250mg $2700.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

2100284-59-9

2100284-59-9 structure

2100284-59-9 structure

Name: AZ 3451
Chemical Name: AZ3451
CAS Number: 2100284-59-9
Molecular Formula: C₃₀H₂₇BrN₄O₃
Molecular Weight: 571.46
Catalog: Signaling Pathways GPCR/G Protein Protease-Activated Receptor (PAR)
Create Date: 2018-09-30 06:20:50
Modify Date: 2023-01-17 10:26:13
AZ3451 is a protease-activated receptor-2 (PAR2) antagonist.

Name	AZ3451

Description	AZ3451 is a protease-activated receptor-2 (PAR2) antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR) Research Areas >> Inflammation/Immunology
Target	Protease-activated receptor-2[1]
In Vitro	Antagonist AZ3451 binds to a remote allosteric site outside the helical bundle of the protease-activated receptor 2. AZ3451 is highly lipophilic, which coincides with the hydrophobic nature of the binding pocket within the membrane. Antagonist binding prevents structural rearrangements required for receptor activation and signalling[1].
References	[1]. Cheng RKY, et al. Structural insight into allosteric modulation of protease-activated receptor 2. Nature. 2017 May 4;545(7652):112-115.

Molecular Formula	C₃₀H₂₇BrN₄O₃
Molecular Weight	571.46
Storage condition	2-8℃