803735-54-8
803735-54-8 structure
- Name: AZ-1
- Chemical Name: AZ-1
- CAS Number: 803735-54-8
- Molecular Formula: C23H31ClN4O2
- Molecular Weight: 430.977
- Create Date: 2020-01-11 17:09:50
- Modify Date: 2023-01-18 17:25:52
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AZ-1 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity; upregulates ABCA1 across multiple CNS cell types, including human astrocytes, pericytes, and microglia, through an indirect LXR mechanism and that also independently inhibit P2X7 receptor activity.
| Name | AZ-1 |
|---|
| Description | AZ-1 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity; upregulates ABCA1 across multiple CNS cell types, including human astrocytes, pericytes, and microglia, through an indirect LXR mechanism and that also independently inhibit P2X7 receptor activity. |
|---|---|
| References | References 1. Fan J, et al. J Lipid Res. 2018 May;59(5):830-842. View Related Products by Target P2X Receptor |
| Molecular Formula | C23H31ClN4O2 |
|---|---|
| Molecular Weight | 430.977 |