Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Thiocolchicine analog
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

87424-26-8

87424-26-8 structure

87424-26-8 structure

Name: Thiocolchicine analog
Chemical Name: N-[(7S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
CAS Number: 87424-26-8
Molecular Formula: C₂₁H₂₃NO₅S
Molecular Weight: 401.47600
Create Date: 2017-06-09 09:27:04
Modify Date: 2024-01-21 18:26:37

Name	N-[(7S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Synonyms	N-((S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide N-((S)-2-Hydroxy-1,3-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid 2-Demethyl Thiocolchicine COLCHICINE,O(sup 2)-DEMETHYL-10-THIO (S)-7-Acetylamino-2-hydroxy-1,3-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on O(sup 2)-Demethyl-10-thiocolchicine

Density	1.33g/cm3
Boiling Point	766.8ºC at 760 mmHg
Melting Point	218-220ºC
Molecular Formula	C₂₁H₂₃NO₅S
Molecular Weight	401.47600
Flash Point	417.6ºC
Exact Mass	401.13000
PSA	110.16000
LogP	3.67280
Index of Refraction	1.636

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0882000

CHEMICAL NAME :: Colchicine, O(sup 2)-demethyl-10-thio-

CAS REGISTRY NUMBER :: 87424-26-8

BEILSTEIN REFERENCE NO. :: 3176298

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H23-N-O5-S

MOLECULAR WEIGHT :: 401.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

2730-71-4 structure

2730-71-4

~3%

87424-26-8 structure

87424-26-8

51296-12-9 structure

51296-12-9

51296-11-8 structure

51296-11-8

Literature: Guan, Jian; Brossi, Arnold; Zhu, Xiao-Kang; Wang, Hui-Kang; Lee, Kuo-Hsiung Synthetic Communications, 1998 , vol. 28, # 9 p. 1585 - 1591

51296-12-9 structure

51296-12-9

18107-18-1 structure

18107-18-1

~%

87424-26-8 structure

87424-26-8

87424-25-7 structure

87424-25-7

Literature: Nakagawa-Goto, Kyoko; Chen, Cyril X.; Hamel, Ernest; Wu, Chin-Chung; Bastow, Kenneth F.; Brossi, Arnold; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 235 - 238

Precursor 3
2730-71-4 51296-12-9 18107-18-1
DownStream 0