Thiocolchicine analog

Modify Date: 2024-01-21 18:26:37

Thiocolchicine analog Structure
Thiocolchicine analog structure
Common Name Thiocolchicine analog
CAS Number 87424-26-8 Molecular Weight 401.47600
Density 1.33g/cm3 Boiling Point 766.8ºC at 760 mmHg
Molecular Formula C21H23NO5S Melting Point 218-220ºC
MSDS N/A Flash Point 417.6ºC

 Names

Name N-[(7S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.33g/cm3
Boiling Point 766.8ºC at 760 mmHg
Melting Point 218-220ºC
Molecular Formula C21H23NO5S
Molecular Weight 401.47600
Flash Point 417.6ºC
Exact Mass 401.13000
PSA 110.16000
LogP 3.67280
Index of Refraction 1.636

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0882000
CHEMICAL NAME :
Colchicine, O(sup 2)-demethyl-10-thio-
CAS REGISTRY NUMBER :
87424-26-8
BEILSTEIN REFERENCE NO. :
3176298
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H23-N-O5-S
MOLECULAR WEIGHT :
401.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25 ug/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

 Synonyms

N-((S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
N-((S)-2-Hydroxy-1,3-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid
2-Demethyl Thiocolchicine
COLCHICINE,O(sup 2)-DEMETHYL-10-THIO
(S)-7-Acetylamino-2-hydroxy-1,3-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on
O(sup 2)-Demethyl-10-thiocolchicine