683239-16-9

683239-16-9 structure

Name: 20-(Tert-Butoxy)-20-Oxoicosanoic Acid
Chemical Name: 20-(Tert-Butoxy)-20-Oxoicosanoic Acid
CAS Number: 683239-16-9
Molecular Formula: C₂₄H₄₆O₄
Molecular Weight: 398.620
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-02-04 17:06:59
Modify Date: 2024-01-03 12:46:22
20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

Name	20-(Tert-Butoxy)-20-Oxoicosanoic Acid
Synonyms	Eicosanedioic acid, mono(1,1-dimethylethyl) ester 20-[(2-Methyl-2-propanyl)oxy]-20-oxoicosanoic acid

Description	20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.