Propargyl-PEG2-amine

Names

[ Name ]:
Propargyl-PEG2-amine

[Synonym ]:
2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanamine
2-(2-(prop-2-ynyloxy)ethoxy)ethanamine

Biological Activity

[Description]:

Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

PEGs

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Changchun Wang, et al. A kind of antibody coupling matter and its construction method containing boron ester units polymer. CN108721642A.

[2]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₃NO₂

[ Molecular Weight ]:
143.18400

[ Exact Mass ]:
143.09500

[ PSA ]:
44.48000

[ LogP ]:
0.31180

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
2735.0

[ Hazard Class ]:
8.0

Related Compounds

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