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Propargyl-PEG2-NHBoc

Names

[ CAS No. ]:
869310-84-9

[ Name ]:
Propargyl-PEG2-NHBoc

[Synonym ]:
[2-(2-prop-2-ynyloxy)-ethyl]-carbamic acid tert.-butyl ester
[2-(2-prop-2-ynyloxy-ethoxy)-ethyl]-carbamic acid tert-butyl ester
[2-(2-Prop-2-ynyloxy-ethoxy)-ethyl]-carbamic acid tert-butyl ester

Biological Activity

[Description]:

Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Cleavable

PEGs

Alkyl/ether


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Nello Mainolfi, et al. rak degraders and uses thereof. US20190192668A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H21NO4

[ Molecular Weight ]:
243.29900

[ Exact Mass ]:
243.14700

[ PSA ]:
56.79000

[ LogP ]:
1.56840

[ Storage condition ]:
2-8℃

Related Compounds