Butyl 4-Hydroxybenzoate

Names

[ CAS No. ]:
94-26-8

[ Name ]:
Butyl 4-Hydroxybenzoate

[Synonym ]:
butyl para-hydroxybenzoate
EINECS 202-318-7
butylbutex
n-Butyl-paraben
SPF
n-butyl-p-hydroxybenzoate
4-Hydroxybenzoic acid butyl ester
preservalb
p-Hydroxybenzoic acid, n-butyl ester
Lexgard B
Mekkings B
Butylparaben
n-butyl para-hydroxybenzoate
4-hydroxybenzoic acid-n-butyl ester
Nipabutyl
4-Hydroxybenzoic acid, butyl ester
Butyl p-hydroxybenzoate
FEMA 2203
butoben
Butyl Paraben
Benzoic acid, 4-hydroxy-, butyl ester
Butyl parasept
solbrolb
p-hydroxybenzoic acid n-butyl ester
p-Hydroxybenzoic acid, butyl ester
p-hydroxybenzoic acid butyl ester
Butyl 4-hydroxybenzoate
MFCD00016478
n-Butyl-4-hydroxybenzoate
UNII-3QPI1U3FV8
Butyl Parahydroxybenzoate
n-butyl 4-hydroxybenzoate
p-Hydroxybenzoic butyl ester
4-Hydroxybenzoic acid n-butyl ester
Tegosept B
n-butylparaben
tegoseptb

Biological Activity

[Description]:

Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
309.2±15.0 °C at 760 mmHg

[ Melting Point ]:
67-70 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₄O₃

[ Molecular Weight ]:
194.227

[ Flash Point ]:
129.2±13.2 °C

[ Exact Mass ]:
194.094299

[ PSA ]:
46.53000

[ LogP ]:
3.46

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.526

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong alkalies.

[ Water Solubility ]:
<0.1 g/100 mL at 17 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH1980000

CHEMICAL NAME :: Benzoic acid, p-hydroxy-, butyl ester

CAS REGISTRY NUMBER :: 94-26-8

BEILSTEIN REFERENCE NO. :: 1103741

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C11-H14-O3

MOLECULAR WEIGHT :: 194.25

WISWESSER LINE NOTATION :: QR DVO4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 28,357,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946- Volume(issue)/page/year: 28,463,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 28,357,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 504 gm/kg/12W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,260,1956 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81355 No. of Facilities: 753 (estimated) No. of Industries: 6 No. of Occupations: 17 No. of Employees: 3511 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81355 No. of Facilities: 704 (estimated) No. of Industries: 10 No. of Occupations: 32 No. of Employees: 24427 (estimated) No. of Female Employees: 18593 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
DH1980000

[ HS Code ]:
2918290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Parabens determination in cosmetic and personal care products exploiting a multi-syringe chromatographic (MSC) system and chemiluminescent detection.

Talanta 143 , 254-62, (2015)

Parabens are widely used in dairy products, such as in cosmetics and personal care products. Thus, in this work a multi-syringe chromatographic (MSC) system is proposed for the first time for the dete...

Development of eczema vaccinatum in atopic mouse models and efficacy of MVA vaccination against lethal poxviral infection.

PLoS ONE 9(12) , e114374, (2014)

Smallpox vaccine based on live, replicating vaccinia virus (VACV) is associated with several potentially serious and deadly complications. Consequently, a new generation of vaccine based on non-replic...

Characterization of in vitro antifungal activities of small and American cranberry (Vaccinium oxycoccos L. and V. macrocarpon Aiton) and lingonberry (Vaccinium vitis-idaea L.) concentrates in sugar reduced fruit spreads.

Int. J. Food Microbiol. 204 , 111-7, (2015)

In this study, cranberry and lingonberry concentrates were added to commercial sugar-reduced fruit spreads (raspberry-Aloe vera, strawberry-guava, and strawberry-lime), and tested for their antifungal...