TNIK inhibitor X
Names
[ CAS No. ]:
933886-36-3
[ Name ]:
TNIK inhibitor X
Biological Activity
[Description]:
TNIK inhibitor X is a potent inhibitor of Traf2- and Nck-interacting kinase (TNIK) (in vitro enzyme IC50=9 nM) with a reasonable selectivity over 30-folds against the majority of a panel of 50 kinases profiled; inhibits cell viability of PAMC82 and T47D cells harboring TNIK amplification with IC50 of 1.77 and 0.385 uM, respectively; shows no inhibitory activity against TNIK-non-amplified AZ-521 cells (IC50>30 uM); suppresses pAKT and induction of LC3 in TNIK-amplified PAMC82 cells, shows minimal effects on either Wnt signaling-mediated transcription.
[References]
References 1. Yu DH, et al. Oncogenesis. 2014 Feb 24;2:e89. 2. Yamada T, et al. TNIK inhibitor and the use. W02010/064111A1. View Related Products by Target TNIK
Chemical & Physical Properties
[ Molecular Formula ]:
C19H17N5O3S
[ Molecular Weight ]:
395.437