ML-191

Names

[ Name ]:
ML-191

[Synonym ]:
3-(1-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-4-piperidinyl)-5-phenyl-1,3,4-oxadiazol-2(3H)-one
1,3,4-Oxadiazol-2(3H)-one, 3-[1-[[1-(4-methylphenyl)cyclopropyl]carbonyl]-4-piperidinyl]-5-phenyl-

Biological Activity

[Description]:

ML-191 is an antagonist of GPR55. It inhibits GPR55 signaling induced by lysophosphatidylinositol (EC50=1.076 µM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC50=328 nM) and receptor-dependent translocation of PKCβII when used at a concentration of 30 µM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> GPR55

[References]

[1]. Heynen-Genel S, et al. Screening for Selective Ligands for GPR55 - Antagonists. 2010 Oct 30

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
569.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₅N₃O₃

[ Molecular Weight ]:
403.474

[ Flash Point ]:
298.2±32.9 °C

[ Exact Mass ]:
403.189606

[ PSA ]:
68.34000

[ LogP ]:
2.75

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.668

ML-191

Names

Biological Activity

Chemical & Physical Properties

Related Compounds