ML 354

Names

[ CAS No. ]:
89159-60-4

[ Name ]:
ML 354

[Synonym ]:
1-methyl-2-hydroxymethyl-3-phenyl-5-nitroindole
1h-indole-2-methanol,1-methyl-5-nitro-3-phenyl

Biological Activity

[Description]:

ML354 is a selective PAR4 antagonist with an IC50 of 140 nM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)

[References]

[1]. Wen W, et al. Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4708-4713.

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
544ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄N₂O₃

[ Molecular Weight ]:
282.29400

[ Flash Point ]:
282.8ºC

[ Exact Mass ]:
282.10000

[ PSA ]:
70.98000

[ LogP ]:
3.76900

[ Index of Refraction ]:
1.646

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
Missing Phrase - N15.00950417

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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