HBX 41108

Names

[ Name ]:
HBX 41108

[Synonym ]:
7-chloro-9-oxoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
HBX41108

Biological Activity

[Description]:

HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase

[References]

[1]. Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8(8):2286-95.

[2]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.

Chemical & Physical Properties

[ Density]:
1.66g/cm3

[ Boiling Point ]:
604.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₃ClN₄O

[ Molecular Weight ]:
266.64200

[ Flash Point ]:
319.6ºC

[ Exact Mass ]:
266.00000

[ PSA ]:
90.43000

[ LogP ]:
2.08476

[ Index of Refraction ]:
1.725

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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