Ibafloxacin

R835 is a fluoroquinolone antibiotic agent that is developed exclusively for veterinary use.

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

The pharmacokinetic behavior of R835 (Ibafloxacin) is studied after intravenous administration of a single dose of 15 mg/kg to 6 healthy lactating goats. Plasma concentrations of R835 are determined by high-performance liquid chromatography with fluorescence detection. After IV injection R835 shows very rapid initial distribution, with a mean half-life of 0.35 h, follows by slower elimination, with a mean half-life of 3.76 h. The elimination half-life of R835 after oral administration has been reported to be 3.83 h in dogs and 3.00 h in cats[1].

Goats[1] Six Murciano-Granadina female goats 52 to 58 kg in body weight (BW) and 3 to 4 y of age are used. A 5% aqueous solution of R835 (Ibafloxacin) is prepared from the pure substance and sterilized. The solution is administered by the IV route as a single dose of 15 mg/kg BW. Blood samples (4 mL) are collected from the contralateral jugular vein into heparinized tubes at 0, 5, 10, 15, 30, and 45 min and at 1, 1.5, 2, 4, 6, 8, 10, 12, 24, 32, 48, and 72 h after drug administration. The samples are centrifuged at 1500× g for 15 min, and then the plasma is removed and stored at -45°C until assayed. Milk samples are collected before and at 1, 2, 4, 6, 12, 24, 32, 48, and 72 h after complete evacuation of the udder at each collection period. The concentration of R835 is measured in plasma and milk by a modified high-performance liquid chromatography (HPLC) method.

[1]. Marín P, et al. Pharmacokinetics and milk penetration of ibafloxacin after intravenous administration to lactating goats. Can J Vet Res. 2007 Jan;71(1):74-6.

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