6,7-Dihydroxycoumarin-4-acetic Acid

Names

[ Name ]:
6,7-Dihydroxycoumarin-4-acetic Acid

[Synonym ]:
2-(6,7-dihydroxy-2-oxochromen-4-yl)acetic acid

Biological Activity

[Description]:

6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase

Research Areas >> Metabolic Disease

[References]

[1]. Kato A, et al. 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5630-3.

Chemical & Physical Properties

[ Melting Point ]:
230ºC

[ Molecular Formula ]:
C₁₁H₈O₆

[ Molecular Weight ]:
236.17800

[ Exact Mass ]:
236.03200

[ PSA ]:
107.97000

[ LogP ]:
0.83130

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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