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K 03861

Names

[ CAS No. ]:
853299-07-7

[ Name ]:
K 03861

[Synonym ]:
1-{4-[(2-Amino-4-pyrimidinyl)oxy]phenyl}-3-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}urea
1-[4-(2-amino-pyrimidin-4-yloxy)-phenyl]-3-[4-(4-methyl-piperazin-1-ylmethyl)-3-rifluoromethyl-phenyl]-urea
Urea, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-
1-[4-(2-aminopyrimidine-4-yloxy)phenyl]-3-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]urea

Biological Activity

[Description]:

K03861 is a type II CDK2 inhibitor with Kd of 8.2 nM.K03861 inhibits CDK2 activity by competing with binding of activating cyclins.

[Related Catalog]:

Research Areas >> Cancer

[Target]

CDK2(C118L/A144C):9.7 nM (Kd)

CDK2(A144C):15.4 nM (Kd)

CDK2(C118L):18.6 nM (Kd)

CDK2(WT):50 nM (Kd)

CDK2(C118L/A144C-Cyclin B):134.1 nM (Kd)


[References]

[1]. Alexander LT et al. Type II Inhibitors Targeting CDK2. ACS Chem Biol. 2015 Sep 18;10(9):2116-25.


[Related Small Molecules]

Abemaciclib(LY2835219) | Ribociclib (LEE011) | Dinaciclib (SCH727965) | THZ1 2HCl | Roscovitine (CYC202) | THZ531 | RO-3306 | Flavopiridol | NVP 2 | BAY-1143572 Racemate | CYC-065 | AZD5438 | BIO | Kenpaullone | SNS-032 (BMS-387032)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C24H26F3N7O2

[ Molecular Weight ]:
501.504

[ Exact Mass ]:
501.210022

[ PSA ]:
108.64000

[ LogP ]:
3.41

[ Index of Refraction ]:
1.642

[ Storage condition ]:
-20℃

Related Compounds