Sudan I

Names

[ CAS No. ]:
842-07-9

[ Name ]:
Sudan I

[Synonym ]:
Sudan J
2-Naphthalenol, 1- (phenylazo)-
2-naphthalenol, 1-[(E)-phenylazo]-
MFCD00003911
1-(2-phenyldiaz-1-enyl)-2-naphthol
Carminaph
1-(Phenyldiazenyl)-2-naphthol
Soudan I
2-Naphthalenol, 1-(2-phenyldiazenyl)-
SCARLET B
1-[(E)-phenyldiazenyl]naphthalen-2-ol
EINECS 212-668-2
SUDAN 1
1-phenylazo-naphthalen-2-ol
2-Naphthalenol, 1-[(E)-2-phenyldiazenyl]-
C.I. Solvent Yellow 14
benzene-1-azo-2-naphthol
SUDAN
1-[(E)-Phenyldiazenyl]-2-naphthol
2-phenylazo-naphthalen-1-ol
1-benzeneazo-2-naphthol
1-(Phenylazo)-2-naphthol
1-Phenylazo-β-naphthol

Biological Activity

[Description]:

Sudan I is an organic compound, typically classified as an azo dye.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Dye Reagents

Research Areas >> Others

[In Vitro]

Sudan I is a monoazo dye with the chemical formula of 1-phenylazo-2-naphthol. Sudan I can cause tumors in the liver or urinary bladder in mammals and is a potential mutagen and carcinogen for humans. Sudan I induces genotoxic effect in HepG2 cells and increases mutagenic and clastogenic effects in the MCL-5 cell lines compared to the AHH-1 cell line. In addition, Sudan I also gives positive results in Salmonella Typhimurium mutagenicity tests with S9 activation, a post-mitochondrial fraction prepared from the livers of rats[1].

[References]

[1]. Pan H, et al. Evaluation of impact of exposure of Sudan azo dyes and their metabolites on human intestinal bacteria. Anaerobe. 2012 Aug;18(4):445-53.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
443.7±28.0 °C at 760 mmHg

[ Melting Point ]:
131-133 °C

[ Molecular Formula ]:
C₁₆H₁₂N₂O

[ Molecular Weight ]:
248.279

[ Flash Point ]:
290.2±13.3 °C

[ Exact Mass ]:
248.094955

[ PSA ]:
44.95000

[ LogP ]:
4.24

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.634

[ Water Solubility ]:
0.5 g/L (30 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL4900000

CHEMICAL NAME :: 2-Naphthol, 1-(phenylazo)-

CAS REGISTRY NUMBER :: 842-07-9

BEILSTEIN REFERENCE NO. :: 0651992

LAST UPDATED :: 199710

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C16-H12-N2-O

MOLECULAR WEIGHT :: 248.30

WISWESSER LINE NOTATION :: L66J BNUNR& CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4200 mg/kg/14D-C

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 87360 mg/kg/13W-C

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10815 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21630 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6000 mg/kg/57W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 96 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 8200 ug/L

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,225,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,225,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2105 No. of Facilities: 1715 (estimated) No. of Industries: 34 No. of Occupations: 32 No. of Employees: 44358 (estimated) No. of Female Employees: 6755 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H341-H351-H413

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R40;R43;R53;R68

[ Safety Phrases ]:
S61-S46-S36/37-S22

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
QL4900000

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Development and validation of a confirmatory HPLC method for simultaneous determination of Sudan dyes in animal tissues and eggs.

J. Chromatogr. Sci. 48(1) , 63-7, (2010)

A simple and sensitive high-performance liquid chromatography (HPLC) analytical method for the simultaneous determination of six Sudan dyes (Sudan Red G, Sudan I, Sudan II, Sudan III, Sudan Red 7B, Su...

Solubilization of two organic dyes by cationic ester-containing gemini surfactants.

J. Colloid. Interface Sci. 376(1) , 112-8, (2012)

Solubilization of two different types of organic dyes, Quinizarin with an anthraquinone structure and Sudan I with an azo structure, has been studied in aqueous solutions of a series of cationic gemin...

Accelerated removal of Sudan dye by Shewanella oneidensis MR-1 in the presence of quinones and humic acids.

World J. Microbiol. Biotechnol. 29(9) , 1723-30, (2013)

Although there have been many studies on bacterial removal of soluble azo dyes, much less information is available for biological treatment of water-insoluble azo dyes. The few bacterial species capab...