Sudan IV

Names

[ CAS No. ]:
85-83-6

[ Name ]:
Sudan IV

[Synonym ]:
1-({2-Methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl)-2-naphthol
o-Tolylazo-o-tolylazo-β-naphthol
Scarlet Red
2-Naphthalenol, 1-[(E)-2-[2-methyl-4-[(E)-2-(2-methylphenyl)diazenyl]phenyl]diazenyl]-
EINECS 201-635-8
solvent red percent24
1-[(E)-{2-Methyl-4-[(E)-(2-methylphenyl)diazenyl]phenyl}diazenyl]-2-naphthol
fatredb
AKA501
1-[(E)-{2-methyl-4-[(E)-(2-methylphenyl)diazenyl]phenyl}diazenyl]naphthalen-2-ol
Solvent Red 24
MFCD00003893
c.i.258
oilredf
2-Naphthalenol, 1-[2-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]diazenyl]-
oilredd
2-Naphthol, 1-[[4-(o-tolylazo)-o-tolyl]azo]-
oilreda
L66J BNUNR B1 DNUNR B1&& CQ
o-Tolylazo-o-tolylazo-b-naphthol
C.I. Solvent Red 24 (8CI)
oilred3
1-[[2-Methyl-4-[(2-methylphenyl)azo]phenyl]azo]-2-naphthalenol
2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-
2-NAPHTHALENOL, 1-((2-METHYL-4-((2-METHYLPHENYL)AZO)PHENYL)AZO)-
sudanp
1-{[2-Methyl-4-(o-tolylazo)phenyl]azo}naphthalen-2-ol
oilred7

Biological Activity

[Description]:

Sudan IV is a lysochrome (fat-soluble dye) diazo dye used for the staining of lipids, triglycerides and lipoproteins on frozen paraffin sections[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Refat NA, et al. The induction of cytochrome P450 1A1 by sudan dyes. J Biochem Mol Toxicol. 2008 Mar-Apr;22(2):77-84.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
618.8±55.0 °C at 760 mmHg

[ Melting Point ]:
199ºC

[ Molecular Formula ]:
C₂₄H₂₀N₄O

[ Molecular Weight ]:
380.442

[ Flash Point ]:
424.4±20.8 °C

[ Exact Mass ]:
380.163696

[ PSA ]:
69.67000

[ LogP ]:
6.66

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.645

[ Water Solubility ]:
Insoluble in water; soluble in benzene, methanol, acetone, isopropanol; slightly soluble in ethanol

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL5775000

CHEMICAL NAME :: 2-Naphthol, 1-((4-(o-tolylazo)-o-tolyl)azo)-

CAS REGISTRY NUMBER :: 85-83-6

BEILSTEIN REFERENCE NO. :: 0709018

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C24-H20-N4-O

MOLECULAR WEIGHT :: 380.48

WISWESSER LINE NOTATION :: L66J BNUNR B1 DNUNR B1&& CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 512 mg/kg/58W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 100 mg/L

REFERENCE :: AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980- Volume(issue)/page/year: 1,241,1980 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,217,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,217,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1356 No. of Facilities: 212 (estimated) No. of Industries: 6 No. of Occupations: 13 No. of Employees: 2432 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1356 No. of Facilities: 1210 (estimated) No. of Industries: 15 No. of Occupations: 23 No. of Employees: 20219 (estimated) No. of Female Employees: 10256 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;T: Toxic;

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QL5775000

[ HS Code ]:
2927000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2927000090

[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Determination of banned 10 azo-dyes in hot chili products by gel permeation chromatography-liquid chromatography-electrospray ionization-tandem mass spectrometry.

J. Chromatogr. A. 1164(1-2) , 120-8, (2007)

An accurate method based on the use of gel permeation chromatography (GPC)-liquid chromatography-tandem mass spectrometry interfaced with electrospray ionization (GPC-LC-ESI-MS/MS) was devised for the...

Development and validation of a confirmatory HPLC method for simultaneous determination of Sudan dyes in animal tissues and eggs.

J. Chromatogr. Sci. 48(1) , 63-7, (2010)

A simple and sensitive high-performance liquid chromatography (HPLC) analytical method for the simultaneous determination of six Sudan dyes (Sudan Red G, Sudan I, Sudan II, Sudan III, Sudan Red 7B, Su...

Analysis and testing of biological stains--the Biological Stain Commission Procedures.

Biotech. Histochem. 77(5&6) , 237-275, (2002)