Raloxifene HCl
Names
[ CAS No. ]:
82640-04-8
[ Name ]:
Raloxifene HCl
[Synonym ]:
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl][4-(2-piperidin-1-ylethoxy)phenyl]methanone hydrochloride
[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(piperidin-1-yl)ethoxy]phenyl}methanone hydrochloride (1:1)
Raloxifene HCl
[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl][4-(2-piperidin-1-ylethoxy)phenyl]methanonhydrochlorid
1-[2-(4-{[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]carbonyl}phenoxy)ethyl]piperidinium chloride
[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(1-piperidinyl)ethoxy]phenyl}methanone hydrochloride (1:1)
Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride (1:1)
methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride
6-Hydroxy-2-(p-hydroxyphenyl)benzo(b)thien-3-yl-p-(2-piperidinoethoxy)phenyl ketone hydrochloride
MFCD01938233
Raloxifene hydrochloride
Raloxifene (hydrochloride)
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.285g/cm3
[ Boiling Point ]:
728.2ºC at 760 mmHg
[ Melting Point ]:
143-147ºC
[ Molecular Formula ]:
C28H28ClNO4S
[ Molecular Weight ]:
510.044
[ Flash Point ]:
394.2ºC
[ Exact Mass ]:
509.142761
[ PSA ]:
98.24000
[ LogP ]:
6.81510
[ Index of Refraction ]:
1.654
[ Storage condition ]:
-20°C Freezer
[ Water Solubility ]:
DMSO: 28 mg/mL, soluble
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
22-24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Drug Metab. Dispos. 42(8) , 1326-33, (2014)
Lenvatinib is a multityrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors, and is being developed as an anticancer drug. P450s are involved in one of the elimination pa...
Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway.J. Steroid Biochem. Mol. Biol. 145 , 85-93, (2015)
Growing evidence shows that steroid hormones, especially 17β-estradiol (E2), protect neuronal cells by attenuating excess activation of microglia. However, the use of E2 in the clinic is controversial...
Bioluminescent cell-based NAD(P)/NAD(P)H assays for rapid dinucleotide measurement and inhibitor screening.Assay Drug Dev. Technol. 12(9-10) , 514-26, (2014)
Abstract The central role of nicotinamide adenine dinucleotides in cellular energy metabolism and signaling makes them important nodes that link the metabolic state of cells with energy homeostasis an...