(1S)-(-)-Alpha-Pinene

Names

[ Name ]:
(1S)-(-)-Alpha-Pinene

[Synonym ]:
(1S,5S)-2,6,6-Trimethyl-bicyclo[3.1.1]hept-2-ene
(1S,5S)-2,6,6-Trimethylbicyclo[3.1.1]hept-2-ene
(1S,5S)-Pin-2-ene
Bicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl-, (1S,5S)-
MFCD00064145
(1S)-(-)-alpha-Pinene
(1S)-(-)-α-Pinene
α-Pinene
EINECS 232-077-3
L46 A EUTJ A1 A1 D1 &&(-)-α or (1S,5S)- Form
(-)-alpha-pinene
Pinene
(1S,5S)-α-Pinene
(1S,5S)-4,6,6-trimethylbicyclo[3.1.1]hept-3-ene

Biological Activity

[Description]:

(-)-α-Pinene is a monoterpene and shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vitro]

(-)-α-pinene enhances the quantity of non-rapid eye movement sleep (NREMS) without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directly binding to the BZD binding site of GABAA receptor[1].

[References]

[1]. Yang H, et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Micethrough GABAA-benzodiazepine Receptors.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
157.9±7.0 °C at 760 mmHg

[ Melting Point ]:
-64ºC

[ Molecular Formula ]:
C₁₀H₁₆

[ Molecular Weight ]:
136.234

[ Flash Point ]:
32.2±0.0 °C

[ Exact Mass ]:
136.125198

[ LogP ]:
4.37

[ Vapour Pressure ]:
3.5±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.479

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H317-H319-H335-H410

[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R10;R36/37/38;R43;R50

[ Safety Phrases ]:
S16-S26-S36/37-S61

[ RIDADR ]:
UN 2052/2368

[ WGK Germany ]:
1

[ Packaging Group ]:
III

[ Hazard Class ]:
3.0

[ HS Code ]:
29021910

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2902199090

[ Summary ]:
2902199090 other cyclanes, cyclenes and cyclotherpenes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%