Amino-PEG6-amine

Names

[ Name ]:
Amino-PEG6-amine

[Synonym ]:
O,O'-bis(2-aminoethyl)pentaethylene glycol
1,20-Diamino-3,6,9,12,15,18-hexaoxaeicosane
2-{2-[2-(2-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethylamine

Biological Activity

[Description]:

Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₃₂N₂O₆

[ Molecular Weight ]:
324.41400

[ Exact Mass ]:
324.22600

[ PSA ]:
107.42000

[ LogP ]:
0.40400

[ Storage condition ]:
2-8°C

Related Compounds

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