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Polyphyllin II

Names

[ CAS No. ]:
76296-72-5

[ Name ]:
Polyphyllin II

[Synonym ]:
β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl O-α-L-arabinofuranosyl-(1->4)-O-[6-deoxy-α-L-mannopyranosyl-(1->3)]-
(3β,25R)-17-Hydroxyspirost-5-en-3-yl α-L-arabinofuranosyl-(1->4)-[6-deoxy-α-L-mannopyranosyl-(1->3)]-β-D-glucopyranoside
PolyphyllinD
N1953
Polyphyllin II

Biological Activity

[Description]:

Polyphyllin II is one of the most significant saponins in Rhizoma Paridis and has toxic effects on kinds of cancer cells. Polyphyllin II induces apoptosis through caspases activation and cell-cycle arrest[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Wang W, et al. Apoptosis in HepaRG and HL-7702 cells inducted by polyphyllin II through caspases activation and cell-cycle arrest. J Cell Physiol. 2019 May;234(5):7078-7089.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C44H70O16

[ Molecular Weight ]:
871.016

[ Exact Mass ]:
870.461304

[ PSA ]:
255.91000

[ LogP ]:
6.02

[ Index of Refraction ]:
1.628

Safety Information

[ Safety Phrases ]:
24/25

[ HS Code ]:
29389090

Related Compounds