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Polyphyllin D

Names

[ CAS No. ]:
50773-41-6

[ Name ]:
Polyphyllin D

[Synonym ]:
β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-α-L-arabinofuranosyl-(1-&gt;4)-O-[6-deoxy-α-L-mannopyranosyl-(1->2)]-
(3β,25R)-Spirost-5-en-3-yl α-L-arabinofuranosyl-(1->4)-[6-deoxy-α-L-mannopyranosyl-(1->2)]-β-D-glucopyranoside
Chonglou saponin I
Polyphyllin A
Polyphyllin Ⅰ

Biological Activity

[Description]:

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Signaling Pathways >> PI3K/Akt/mTOR >> PDK-1
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Signaling Pathways >> MAPK/ERK Pathway >> JNK

[Target]

JNK signaling[2] PDK1/Akt/mTOR signaling[3]


[References]

[1]. Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33.

[2]. Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486.

[3]. He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C44H70O16

[ Molecular Weight ]:
855.017

[ Exact Mass ]:
854.466370

[ PSA ]:
235.68000

[ LogP ]:
7.12

[ Index of Refraction ]:
1.618

Safety Information

[ HS Code ]:
29389090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds