MMAF
Names
[ CAS No. ]:
745017-94-1
[ Name ]:
MMAF
[Synonym ]:
MMAF
L-Valinamide, N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
Monomethylauristatin F
N-Methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-3-methoxy-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valinamide
Monomethyl auristatin phenylalanine
Monomethyl auristatin F
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 119 nM (Cytotoxicity, Karpas 299 cell), 105 nM (Cytotoxicity, H3396 cell), 257 nM (Cytotoxicity, 786-O cell), 200 nM (Cytotoxicity, Caki-1, cell)[1]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
896.8±65.0 °C at 760 mmHg
[ Molecular Formula ]:
C39H65N5O8
[ Molecular Weight ]:
731.962
[ Flash Point ]:
496.2±34.3 °C
[ Exact Mass ]:
731.483337
[ PSA ]:
173.59000
[ LogP ]:
4.36
[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.522
[ Storage condition ]:
2-8℃