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3-(2-Pyridyldithio)propanoic Acid

Names

[ CAS No. ]:
68617-64-1

[ Name ]:
3-(2-Pyridyldithio)propanoic Acid

[Synonym ]:
2-carboxyethyl-pyridin-2-yldisulphide
3-(2-Pyridinyldithio)propanoic Acid
3-(2-Pyridyldithio)propanoic acid
Propanoic acid,3-(2-pyridinyldithio)
2-Carboxyethyl 2-Pyridyl Disulfide
3-(PYRIDIN-2-YLDITHIO)PROPANOIC ACID
3-(2-pyridinyldisulfanyl)propanoic acid
3-(pyridin-2-yldithio)-propionic acid
3-(2-Pyridyldithio)propionic acid
3-(pyridin-2-yldisulfanyl)propionic acid

Biological Activity

[Description]:

3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Melting Point ]:
68-71C

[ Molecular Formula ]:
C8H9NO2S2

[ Molecular Weight ]:
215.29300

[ Exact Mass ]:
215.00700

[ PSA ]:
100.79000

[ LogP ]:
2.29660

[ Storage condition ]:
-20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds