Ansamitocin P-3
Names
[ CAS No. ]:
66547-09-9
[ Name ]:
Ansamitocin P-3
[Synonym ]:
maytansinol 3-butyrate
Propanoic acid, 2-methyl-, (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10,12,1
 4(26),16,18-pentaen-6-yl ester
C32H43ClN2O9
Maytansinol butyrate
(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2- methylpropanoate
Ansamitocin P-3
MFCD00274586
Ansamitocin P 3'
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
833.1±65.0 °C at 760 mmHg
[ Melting Point ]:
182-185℃
[ Molecular Formula ]:
C32H43ClN2O9
[ Molecular Weight ]:
635.145
[ Flash Point ]:
457.7±34.3 °C
[ Exact Mass ]:
634.265686
[ PSA ]:
136.16000
[ LogP ]:
5.09
[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C
[ Index of Refraction ]:
1.583
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OQ2293000
- CHEMICAL NAME :
- Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, butyrate (ester)
- CAS REGISTRY NUMBER :
- 66547-09-9
- LAST UPDATED :
- 199401
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C32-H43-Cl-N2-O9
- MOLECULAR WEIGHT :
- 635.22
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 625 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-130495
Safety Information
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R20/22;R36/37/38
[ Safety Phrases ]:
S26;S36
[ WGK Germany ]:
3
[ RTECS ]:
OQ2293000