Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-

Names

[ CAS No. ]:
664-95-9

[ Name ]:
Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-

[Synonym ]:
Glicosil
TOLCYCLAMIDE
Gliciclamide
1-cyclohexyl-3-tosylurea
Cyclamide
Glycyclamid
N-cyclohexyl-N'-(toluene-4-sulfonyl)-urea
Agliral
Cyclamid
N-Cyclohexyl-N'-(toluol-4-sulfonyl)-harnstoff
Cychloral
N1-p-Toluolsulfonyl-N2-cyclohexylharnstoff
Glycyclamide
Tolhexamide
N-(cyclohexylcarbamoyl)-4-methylbenzenesulfonamide

Biological Activity

[Description]:

Cyclamide (Cicloral), an oligopeptide, can be produced by cyanobacteria algae strains. Cyclamide can be used for the research of diabetes mellitus[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. GRINCHENKO TS, et, al. CYCLAMIDE (K-386) TREATMENT OF DIABETES MELLITUS. Fed Proc Transl Suppl. Jul-Aug 1964;23:767-8.

[2]. Natumi R, et, al. Cyanobacterial Toxins and Cyanopeptide Transformation Kinetics by Singlet Oxygen and pH-Dependence in Sunlit Surface Waters. Environ Sci Technol. 2021 Nov 16;55(22):15196-15205.

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Molecular Formula ]:
C₁₄H₂₀N₂O₃S

[ Molecular Weight ]:
296.39

[ Exact Mass ]:
296.11900

[ PSA ]:
83.65000

[ LogP ]:
4.17820

[ Index of Refraction ]:
1.578

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS7800000

CHEMICAL NAME :: Urea, 1-cyclohexyl-3-(p-tolylsulfonyl)-

CAS REGISTRY NUMBER :: 664-95-9

BEILSTEIN REFERENCE NO. :: 1995860

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H20-N2-O3-S

MOLECULAR WEIGHT :: 296.42

WISWESSER LINE NOTATION :: L6TJ AMVMSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 12,268,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,280,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 800 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 28,616,1965

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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