Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-
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664-95-9

664-95-9 structure

Name: Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-
Chemical Name: 1-cyclohexyl-3-(4-methylphenyl)sulfonylurea
CAS Number: 664-95-9
Molecular Formula: C₁₄H₂₀N₂O₃S
Molecular Weight: 296.39
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-08-15 11:57:04
Modify Date: 2024-01-06 20:01:04
Cyclamide (Cicloral), an oligopeptide, can be produced by cyanobacteria algae strains. Cyclamide can be used for the research of diabetes mellitus[1][2].

Name	1-cyclohexyl-3-(4-methylphenyl)sulfonylurea
Synonyms	Glicosil TOLCYCLAMIDE Gliciclamide 1-cyclohexyl-3-tosylurea Cyclamide Glycyclamid N-cyclohexyl-N'-(toluene-4-sulfonyl)-urea Agliral Cyclamid N-Cyclohexyl-N'-(toluol-4-sulfonyl)-harnstoff Cychloral N1-p-Toluolsulfonyl-N2-cyclohexylharnstoff Glycyclamide Tolhexamide N-(cyclohexylcarbamoyl)-4-methylbenzenesulfonamide

Description	Cyclamide (Cicloral), an oligopeptide, can be produced by cyanobacteria algae strains. Cyclamide can be used for the research of diabetes mellitus[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. GRINCHENKO TS, et, al. CYCLAMIDE (K-386) TREATMENT OF DIABETES MELLITUS. Fed Proc Transl Suppl. Jul-Aug 1964;23:767-8. [2]. Natumi R, et, al. Cyanobacterial Toxins and Cyanopeptide Transformation Kinetics by Singlet Oxygen and pH-Dependence in Sunlit Surface Waters. Environ Sci Technol. 2021 Nov 16;55(22):15196-15205.

Density	1.26g/cm3
Molecular Formula	C₁₄H₂₀N₂O₃S
Molecular Weight	296.39
Exact Mass	296.11900
PSA	83.65000
LogP	4.17820
Index of Refraction	1.578

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS7800000

CHEMICAL NAME :: Urea, 1-cyclohexyl-3-(p-tolylsulfonyl)-

CAS REGISTRY NUMBER :: 664-95-9

BEILSTEIN REFERENCE NO. :: 1995860

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H20-N2-O3-S

MOLECULAR WEIGHT :: 296.42

WISWESSER LINE NOTATION :: L6TJ AMVMSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 12,268,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,280,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 800 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 28,616,1965

70-55-3

3173-53-3

~95%

664-95-9

Literature: Cervello; Sastre Synthesis, 1990 , # 3 p. 221 - 222

4083-64-1

108-91-8

~33%

664-95-9

Literature: Howbert; Grossman; Crowell; Rieder; Harper; Kramer; Tao; Aikins; Poore; Rinzel; Grindey; Shaw; Todd Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2393 - 2407

5577-13-9

108-91-8

~75%

664-95-9

Literature: Xi, Pin-xian; Xu, Zhi-hong; Liu, Xiao-hui; Cheng, Feng-juan; Zeng, Zheng-zhi Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 71, # 2 p. 523 - 528 Title/Abstract Full Text View citing articles Show Details Xi, Pin-Xian; Xu, Zhi-Hong; Liu, Xiao-Hui; Chen, Feng-Juan; Huang, Liang; Zeng, Zheng-Zhi Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 541 - 546