cyclohexylisocyanate
Names
[ CAS No. ]:
3173-53-3
[ Name ]:
cyclohexylisocyanate
[Synonym ]:
cyclohexyl-NCO
chi
Cyclohexyl isocyanate
cyclohexylisocyanate
Cyclohexane, isocyanato-
isocyanato-cyclohexan
Isocyanatocyclohexane
Isocyanic Acid Cyclohexyl Ester
EINECS 221-639-3
c-hexylisocyanate
cyclohexanyl isocyanate
cyclohexyl
MFCD00003840
cyclohexane,isocyanato
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
169.0±9.0 °C at 760 mmHg
[ Melting Point ]:
-80 °C
[ Molecular Formula ]:
C7H11NO
[ Molecular Weight ]:
125.168
[ Flash Point ]:
48.9±0.0 °C
[ Exact Mass ]:
125.084061
[ PSA ]:
29.43000
[ LogP ]:
2.89
[ Vapour Pressure ]:
1.6±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.523
[ Stability ]:
Stability Flammable. Incompatible with water, strong oxidizing agents, alcohols, strong bases, amines, acids, copper alloys, aluminium. May polymerize if exposed to moisture.
[ Water Solubility ]:
decomposes
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NQ8650000
- CHEMICAL NAME :
- Isocyanic acid, cyclohexyl ester
- CAS REGISTRY NUMBER :
- 3173-53-3
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C7-H11-N-O
- MOLECULAR WEIGHT :
- 125.19
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 150 ug/plate
- REFERENCE :
- ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 44,3017,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0838 No. of Facilities: 48 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 457 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H302 + H312-H315-H317-H319-H330-H334-H335
[ Precautionary Statements ]:
P260-P280-P284-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;
[ Risk Phrases ]:
R10;R21/22;R26;R34;R42;R50
[ Safety Phrases ]:
S26-S28-S36/37-S45-S57-S36/37/39-S29-S28A-S23-S16
[ RIDADR ]:
UN 2488 6.1/PG 1
[ WGK Germany ]:
2
[ RTECS ]:
NQ8650000
[ Packaging Group ]:
I
[ Hazard Class ]:
6.1
[ HS Code ]:
29291090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2929109000
[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Eur. J. Pharm. Biopharm. 80(1) , 203-8, (2012)
A glibenclamide polymorph published by Panagopoulou-Kaplani and Malamataris (2000) [1], obtained by sublimation of amorphous glibenclamide, was analysed. A new interpretation of the data is presented ...
Effect of nitrosoureas on calmodulin activity in vitro and in mouse intestine in vivo.Cancer Chemother. Pharmacol. 14(2) , 146-9, (1985)
The effects of BCNU, CCNU, methyl-CCNU, streptozotocin, and chlorozotocin on calmodulin activity were studied in vitro and in vivo. Preincubation of BCNU, CCNU, and methyl-CCNU with calmodulin produce...
Synthesis of HMDI-based segmented polyurethanes and their use in the manufacture of elastomeric composites for cardiovascular applications.J. Biomater. Sci. Polym. Ed. 18(5) , 561-78, (2007)
For short-term cardiovascular application, segmented polyurethanes (SPUs) based on 4,4-methylenebis(cyclohexyl isocyanate) (HMDI), polytetramethylenglycol (PTMG) and 1,4-butanediol (BD) were synthesiz...