Mating Factor α acetate salt

Names

[ Name ]:
Mating Factor α acetate salt

[Synonym ]:
alpha1-Mating Factor acetate salt
alpha1-MATING FACTOR
MFCD00133883
Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr
A1-Mating Factor acetate salt
WHWLQLKPGQPMY
α-Factor Mating Pheromone, yeast

Biological Activity

[Description]:

α-Factor Mating Pheromone, yeast is a tridecapeptide secreted by S. cerevisiae α cells via Ste2p receptor.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

Peptides

[Target]

Ste2p[1]

[In Vitro]

α-Factor Mating Pheromone, yeast is synthesized constitutively by MATα cells and acting on MATa cells[1]. α-Factor Mating Pheromone, yeast inhibits the division cycle of yeast a cells, and competes for binding of 35S-α-factor to haploid a cells, with Kd of 0.3 μM, and this binding is related to five temperature-sensitive ste2 mutants, and is thermolabile. However, α-Factor Mating Pheromone, yeast binding activity of other temperature-sensitive mutants (ste4, ste5, ste7, ste11, and ste12) shows no thermolability[2].

[References]

[1]. Naider F, et al. The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors. Peptides. 2004 Sep;25(9):1441-63.

[2]. Jenness DD, et al. Binding of alpha-factor pheromone to yeast a cells: chemical and genetic evidence for an alpha-factor receptor. Cell. 1983 Dec;35(2 Pt 1):521-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.338 g/cm3

[ Boiling Point ]:
1995.8ºC at 760 mmHg

[ Molecular Formula ]:
C₈₂H₁₁₄N₂₀O₁₇S

[ Molecular Weight ]:
1683.97000

[ Exact Mass ]:
1682.84000

[ PSA ]:
612.93000

[ LogP ]:
6.31310

[ Index of Refraction ]:
1.625

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 1 mg/mL, clear, colorless | Soluble in water at 1mg/ml

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Synthesis of the mating factor of Saccharomyces cerevisiae and its truncated peptides : the structure-activity relationship.

Biochem. Biophys. Res. Commun. 78 , 534, (1977)

Gcn5p plays an important role in centromere kinetochore function in budding yeast.

Mol. Cancer Ther. 28 , 988-96, (2008)

We report that the histone acetyltransferase Gcn5p is involved in cell cycle progression, whereas its absence induces several mitotic defects, including inefficient nuclear division, chromosome loss, ...

Related Compounds

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