MRS 1845

Names

[ CAS No. ]:
544478-19-5

[ Name ]:
MRS 1845

[Synonym ]:
MRS 1845
N-Propargylnitrendipene

Biological Activity

[Description]:

MRS1845 is a Ca2+ channel blocker with relative specificity for store-operated calcium entry (SOCE) channels[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Cardiovascular Disease

[Target]

Ca2+ channel[1]

[References]

[1]. Lee C, et al. Store-operated calcium channel inhibition attenuates neutrophil function and postshock acute lung injury. J Trauma. 2005 Jul;59(1):56-63.

Chemical & Physical Properties

[ Density]:
1.318g/cm3

[ Boiling Point ]:
530.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₂N₂O₆

[ Molecular Weight ]:
398.41

[ Flash Point ]:
274.8ºC

[ Exact Mass ]:
398.14800

[ PSA ]:
101.66000

[ LogP ]:
3.37240

[ Index of Refraction ]:
1.595

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.

PLoS ONE 8 , e82180, (2013)

Limited information is available on the brain expression and role of GPR35, a Gi/o coupled receptor activated by kynurenic acid (KYNA). In mouse cultured astrocytes, we detected GPR35 transcript using...