MRS 1706

MRS-1706 is a potent and selective A(2B) adenosine receptor antagonist with a Ki value of 1.39 nM.

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

Research Areas >> Inflammation/Immunology

IC50: 1.39 nM (A(2B) human adenosine receptor)[1].

MRS-1706 is a selective adenosine A2B receptor inverse agonist with Ki values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively[1]. Pretreatment with ZM241385 (A2A-Ado receptor antagonist) alone or in combination with MRS-1706 (A2B-Ado receptor antagonist) results in a pure constriction upon adenosine[2].

[1]. Kim YC, et al. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J Med Chem. 2000 Mar 23;43(6):1165-72.

[2]. Lai EY, et al. Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction. Kidney Int. 2006 Aug;70(4):690-8.

CGS 21680 hydrochloride | Preladenant | ZM 241385 | CPI-444 | SCH 58261 | Vipadenant | Istradefylline | Tozadenant | AZD-4635 | Capadenoson | 2-CL-IB-MECA | PSB-12379 | CD73-IN-1 | IB-MECA | Diprophylline