SID 3712249

Names

[ Name ]:
SID 3712249

[Synonym ]:
1,8-Diamino-3,6-di(pyrrolidin-1-yl)-2,7-naphthyridine-4-carbonitrile
MFCD03483890
1,8-Diamino-3,6-di(1-pyrrolidinyl)-2,7-naphthyridine-4-carbonitrile
2,7-Naphthyridine-4-carbonitrile, 1,8-diamino-3,6-di-1-pyrrolidinyl-

Biological Activity

[Description]:

SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> MicroRNA

Research Areas >> Cancer

[References]

[1]. Zhi Q, et al. Oncogenic miR-544 is an important molecular target in gastric cancer. Anticancer Agents Med Chem. 2013 Feb;13(2):270-5.

[Related Small Molecules]

MIR96-IN-1 | Lin28-let-7a antagonist 1 | Targapremir 210

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
669.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₁N₇

[ Molecular Weight ]:
323.396

[ Flash Point ]:
358.4±31.5 °C

[ Exact Mass ]:
323.185852

[ LogP ]:
2.27

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.731

[ Storage condition ]:
2-8℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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