522606-67-3
522606-67-3 structure
- Name: SID 3712249
- Chemical Name: SID 3712249
- CAS Number: 522606-67-3
- Molecular Formula: C17H21N7
- Molecular Weight: 323.396
- Catalog: Signaling Pathways Epigenetics MicroRNA
- Create Date: 2018-03-10 08:13:21
- Modify Date: 2025-08-27 11:38:59
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SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.
| Name | SID 3712249 |
|---|---|
| Synonyms |
1,8-Diamino-3,6-di(pyrrolidin-1-yl)-2,7-naphthyridine-4-carbonitrile
MFCD03483890 1,8-Diamino-3,6-di(1-pyrrolidinyl)-2,7-naphthyridine-4-carbonitrile 2,7-Naphthyridine-4-carbonitrile, 1,8-diamino-3,6-di-1-pyrrolidinyl- |
| Description | SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 669.0±55.0 °C at 760 mmHg |
| Molecular Formula | C17H21N7 |
| Molecular Weight | 323.396 |
| Flash Point | 358.4±31.5 °C |
| Exact Mass | 323.185852 |
| LogP | 2.27 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.731 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
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