Amino-PEG11-amine
Names
[ CAS No. ]:
479200-82-3
[ Name ]:
Amino-PEG11-amine
[Synonym ]:
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diamine
Biological Activity
[Description]:
Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].
[Related Catalog]:
[Target]
PEGs
[In Vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[References]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
591.2±45.0 °C at 760 mmHg
[ Molecular Formula ]:
C24H52N2O11
[ Molecular Weight ]:
544.677
[ Flash Point ]:
299.9±22.4 °C
[ Exact Mass ]:
544.357117
[ LogP ]:
-4.81
[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C
[ Index of Refraction ]:
1.468
[ Storage condition ]:
2-8°C