479200-82-3

479200-82-3 structure
479200-82-3 structure
  • Name: Amino-PEG11-amine
  • Chemical Name: 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diamine
  • CAS Number: 479200-82-3
  • Molecular Formula: C24H52N2O11
  • Molecular Weight: 544.677
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-09-18 10:41:49
  • Modify Date: 2024-01-18 16:07:08
  • Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].

Name 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diamine
Synonyms 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diamine
Description Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15.

Density 1.1±0.1 g/cm3
Boiling Point 591.2±45.0 °C at 760 mmHg
Molecular Formula C24H52N2O11
Molecular Weight 544.677
Flash Point 299.9±22.4 °C
Exact Mass 544.357117
LogP -4.81
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.468
Storage condition 2-8°C