Bekanamycin

Names

[ Name ]:
Bekanamycin

[Synonym ]:
4,6-Diamino-3-[(3-amino-3-deoxyhexopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxyhexopyranoside
aminodeoxykanamycin
NK-1006
α-D-Glucopyranoside, (1S,2R,3R,4S,6R)-4,6-diamino-3-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-
KANAMYCIN B
Hexopyranoside, 4,6-diamino-3-[(3-amino-3-deoxyhexopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-
kananmycin B
kdm
nebramycinfactor5
Bekanamycin
kanendomycin
(1S,2R,3R,4S,6R)-4,6-Diamino-3-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside
nebramycinv

Biological Activity

[Description]:

Bekanamycin is an aminoglycoside antibiotic.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Natural Products >> Others

Research Areas >> Infection

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
807.7±65.0 °C at 760 mmHg

[ Melting Point ]:
178-182° (dec)

[ Molecular Formula ]:
C₁₈H₃₇N₅O₁₀

[ Molecular Weight ]:
483.514

[ Flash Point ]:
442.3±34.3 °C

[ Exact Mass ]:
483.254028

[ PSA ]:
288.40000

[ LogP ]:
-2.93

[ Vapour Pressure ]:
0.0±6.5 mmHg at 25°C

[ Index of Refraction ]:
1.668

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK1975000

CHEMICAL NAME :: D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6 -diamino-2,6-dideoxy- alpha-D-glucopyranosyl-(1-6))-2-deoxy-

CAS REGISTRY NUMBER :: 4696-76-8

BEILSTEIN REFERENCE NO. :: 0061646

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H37-N5-O10

MOLECULAR WEIGHT :: 483.60

WISWESSER LINE NOTATION :: T6OTJ CZ DQ EQ F1Z BO- BL6TJ AZ CQ EZ DO- BT6OTJ CQ DZ EQ F1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 1,159,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 1,159,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 132 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 27,677,1974

Precursor & DownStream

Precursor

DownStream

Related Compounds

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