TNF-α-IN-1

Names

[ CAS No. ]:
444287-49-4

[ Name ]:
TNF-α-IN-1

[Synonym ]:
Acetamide, 2-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]methyl]-
2-Chloro-N-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]methyl}acetamide

Biological Activity

[Description]:

TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7.

[Related Catalog]:

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Research Areas >> Inflammation/Immunology
Research Areas >> Cancer

[Target]

TNF-α[1]


[References]

[1]. Robarge M, et al. Isoindole-imide compounds, compositions, and uses thereof. US20030096841A1


[Related Small Molecules]

E3 ligase Ligand 1 | TC E3 5031 | VH 298 | 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione | Thalidomide fluoride | E3 ligase Ligand 5 | E3 ligase Ligand 6

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
718.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H14ClN3O5

[ Molecular Weight ]:
363.753

[ Flash Point ]:
388.4±32.9 °C

[ Exact Mass ]:
363.062195

[ LogP ]:
-0.66

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.632

Related Compounds