E3 ligase Ligand 6

Protein degrader 1 TFA is a small molecule ligand for VHL, an E3 ligase which has been targeted in numerous PROTACs.

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

Research Areas >> Cancer

E3 ligase VHL[1]

Synthesis of HaloPROTACs contains Protein degrader 1 (Degradation Inducing Moiety A). Protein degrader 1 (Degradation Inducing Moiety A) is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. HaloPROTACs containing Protein degrader 1 (Degradation Inducing Moiety A) lead to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used[1].

[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

E3 ligase Ligand 1 | TC E3 5031 | VH 298 | 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione | Thalidomide fluoride | E3 ligase Ligand 5 | TNF-α-IN-1