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CK 666

Names

[ CAS No. ]:
442633-00-3

[ Name ]:
CK 666

[Synonym ]:
2-fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide
CK-666

Biological Activity

[Description]:

CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1].

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex
Research Areas >> Others

[Target]

Arp2/3 complex[1]


[References]

[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H17FN2O

[ Molecular Weight ]:
296.33900

[ Exact Mass ]:
296.13200

[ PSA ]:
48.38000

[ LogP ]:
4.16270

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Precursor & DownStream

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Related Compounds