A2AR-agonist-1

Names

[ Name ]:
A2AR-agonist-1

[Synonym ]:
N6-(4-hydroxybenzyl)adenosine
N6-(2-(3-indolyl)ethyl)adenosine
N6-[2-(indol-3-yl)ethyl]adenosine
(2R,3S,4R,5R)-2-Hydroxymethyl-5-{6-[2-(1H-indol-3-yl)-ethylamino]-purin-9-yl}-tetrahydro-furan-3,4-diol
6-[2-(3-Indolyl)ethylamino]-9-(β-D-ribofuranosyl)purine
N6-(2-indol-3-yl-ethyl)-adenosine
A2AR-agonist-1

Biological Activity

[Description]:

A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1.IC50 value: 4.39 and 3.47 (Ki) [1]Target: A2AR and ENT1A2AR-agonist-1 is a novel dual-action compound, targeting the Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection.[1]

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Chen JB, et al. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. 2011 Aug 1;6(8):1390-1400.

[2]. Lin Yun-Lian, et al. Dual-action compounds targeting adenosine A2A receptor and adenosine transporter for prevention and treatment of neurodegenerative diseases. From PCT Int. Appl. (2012), WO 2012064340 A1 20120518.

[3]. Chen, Chih-Cheng, et al. Methods and compositions for treating pain. From PCT Int. Appl. (2013), WO 2013120078 A1 20130815.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₂N₆O₄

[ Molecular Weight ]:
410.42600

[ Exact Mass ]:
410.17000

[ PSA ]:
141.34000

[ LogP ]:
0.64670

[ Storage condition ]:
2-8℃

Related Compounds

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