Pentaethylene glycol di(p-toluenesulfonate)

Names

[ Name ]:
Pentaethylene glycol di(p-toluenesulfonate)

[Synonym ]:
Pentaethylene glycol di-p-toluenesulfonate
2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
MFCD00012204

Biological Activity

[Description]:

Pentaethylene glycol di(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Density]:
1.26

[ Boiling Point ]:
661.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₄H₃₄O₁₀S₂

[ Molecular Weight ]:
546.65100

[ Flash Point ]:
353.8ºC

[ Exact Mass ]:
546.15900

[ PSA ]:
140.42000

[ LogP ]:
4.64220

[ Index of Refraction ]:
n20/D 1.524(lit.)

[ Water Solubility ]:
Not miscible or difficult to mix in water.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Pure Appl. Chem. 65 , 585, (1993)

Tetrahedron 49 , 6019, (1993)

Chem Express 8 , 471, (1993)