41024-91-3

41024-91-3 structure

Name: Pentaethylene glycol di(p-toluenesulfonate)
Chemical Name: penta(ethylene glycol) di-p-toluenesulfonate
CAS Number: 41024-91-3
Molecular Formula: C₂₄H₃₄O₁₀S₂
Molecular Weight: 546.65100
Catalog: Chemical reagent Organic reagent Tosylate
Create Date: 2018-05-07 08:00:00
Modify Date: 2025-08-25 12:49:07
Pentaethylene glycol di(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	penta(ethylene glycol) di-p-toluenesulfonate
Synonyms	Pentaethylene glycol di-p-toluenesulfonate 2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate MFCD00012204

Description	Pentaethylene glycol di(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Density	1.26
Boiling Point	661.4ºC at 760mmHg
Molecular Formula	C₂₄H₃₄O₁₀S₂
Molecular Weight	546.65100
Flash Point	353.8ºC
Exact Mass	546.15900
PSA	140.42000
LogP	4.64220
Index of Refraction	n20/D 1.524(lit.)
Water Solubility	Not miscible or difficult to mix in water.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2909499000

4792-15-8

98-59-9

~10%

41024-91-3

155130-15-7

Literature: Bouzide, Abderrahim; Sauve, Gilles Organic Letters, 2002 , vol. 4, # 14 p. 2329 - 2332

4792-15-8

98-59-9

~99%

41024-91-3

Literature: Bonger, Kimberly M.; van den Berg, Richard J.B.H.N.; Heitman, Laura H.; IJzerman, Ad P.; Oosterom, Julia; Timmers, Cornelis M.; Overkleeft, Herman S.; van der Marel, Gijsbert A. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 4841 - 4856

107-21-1

112-26-5

98-59-9

41024-91-3

Literature: Fenton, David E.; Parkin, Donald; Newton, Roger F. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 449 - 454

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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