GW3965 HCl
Names
[ CAS No. ]:
405911-17-3
[ Name ]:
GW3965 HCl
[Synonym ]:
2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid,hydrochloride
Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride (1:1)
[3-(3-{[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid hydrochloride (1:1)
GW-3965 hydrochloride
GW3965 HCl
GW3965 (hydrochloride)
Biological Activity
[Description]:
[Related Catalog]:
[Target]
EC50: 190 nM (hLXRα), 30 nM (hLXRβ)[4]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[3]. Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761.
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C33H32Cl2F3NO3
[ Molecular Weight ]:
618.513
[ Exact Mass ]:
617.171143
[ PSA ]:
49.77000
[ LogP ]:
8.89110
[ Storage condition ]:
-20℃
MSDS
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H318-H413
[ Precautionary Statements ]:
P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ RIDADR ]:
NONH for all modes of transport
Articles
Adv. Healthc. Mater. 3(9) , 1448-56, (2014)
Liver X receptors (LXRs) attenuate inflammation by modulating the expression of key inflammatory genes, making LXRs and their ligands particularly attractive candidates for therapeutic intervention in...
Pleiotropic effects of antitumour alkylphospholipids on cholesterol transport and metabolism.Exp. Cell Res. 340 , 81-90, (2016)
Alkylphospholipid (APL) analogs are a new class of membrane-directed synthetic compounds with a variety of biological actions and clinical applications. In particular, these agents are promising candi...
Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile.PLoS ONE 6 , e20240, (2011)
Recent studies have suggested that periodontal disease increases the risk of atherothrombotic disease. Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol depositi...