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Ophiopogonin B

Names

[ CAS No. ]:
38971-41-4

[ Name ]:
Ophiopogonin B

[Synonym ]:
α-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl 6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)-
4-Octacosanone,24-hydroxy
24-hydroxy-4-octacosanone
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)-α-D-galactopyranoside

Biological Activity

[Description]:

Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> JNK

[Target]

JNK


[In Vitro]

Ophiopogonin B (0, 5, 10and 20 μM) suppresses the proliferation of HT-29 and HCT-116 cell lines through the G0/G1 phase cell cycle arrest[1]. Ophiopogonin B induces apoptosis by inhibiting the expression of Bax and cleaved caspase 3 and promoting the expression of Bcl-2. Treatment with Ophiopogonin B also increases the expression of Beclin 1 and the conversion of LC3I to LC3II with the activation of JNK/c-Jun signaling pathway[1].

[References]

[1]. Gao GY, et al. Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Biomed Pharmacother. 2018 Dec;108:1208-1215. 

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
835.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C39H62O12

[ Molecular Weight ]:
722.902

[ Flash Point ]:
459.2±34.3 °C

[ Exact Mass ]:
722.424133

[ PSA ]:
176.76000

[ LogP ]:
5.63

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.604

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds