Ruscogenin

Names

[ CAS No. ]:
472-11-7

[ Name ]:
Ruscogenin

[Synonym ]:
(1β,3β,25R)-Spirost-5-ene-1,3-diol
25D-Spirost-5-ene-1|A,3|A-diol
(25R)-Spirost-5-ene-1b,3b-diol
(25R)-Spirost-5-ene-1β,3β-diol
(1β,3β,25R)-Spirost-5-en-1,3-diol
Spirost-5-en-1,3-diol, (1β,3β,25R)-

Biological Activity

[Description]:

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)

[References]

[1]. Cao G, et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418.

[2]. Huang YL, et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108(2):198-205.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
563.1±50.0 °C at 760 mmHg

[ Melting Point ]:
198-202ºC

[ Molecular Formula ]:
C₂₇H₄₂O₄

[ Molecular Weight ]:
430.62

[ Flash Point ]:
294.4±30.1 °C

[ Exact Mass ]:
430.308319

[ PSA ]:
58.92000

[ LogP ]:
4.29

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.577

[ Storage condition ]:
2~8℃

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29389090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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