2',3'-O-Isopropylideneadenosine

Names

[ CAS No. ]:
362-75-4

[ Name ]:
2',3'-O-Isopropylideneadenosine

[Synonym ]:
2',3'-O-(1-methylethylidene)adenosine
9-(2,3-O-Isopropylidene-β-D-ribofuranosyl)adenine
2',3'-O-Isopropylideneadenosine
2,3-O-Isopropylideneadenosine
[(3aR,4R,6R,6aR)-6-(6-Amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methanol
Adenosine, 2',3'-O-(1-methylethylidene)-
3-(1'-O-methyl-2',3'-O-isopropylidene-5'-amino-5'-deoxy-
2',3'-ISOPROPYLIDENEADENOSINE
EINECS 206-650-3
2,3-Isopropylideneadeosine
2’,3’-O-Isopropylideneadenosine
2',3'-IPA
2',3'-o-Isopropylideneadenosin
2'-O,3'-O-Isopropylideneadenosine
MFCD00005756
2',3'-O-Isopropylidene-D-adenosine
ISOPROPYLIDENE ADENOSINE
2',3'-O-isopropylidene-adenosine
2‘,3‘-O-Isopropylideneadenosine

Biological Activity

[Description]:

2',3'-O-Isopropylideneadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
570.5±60.0 °C at 760 mmHg

[ Melting Point ]:
221-222 °C(lit.)

[ Molecular Formula ]:
C₁₃H₁₇N₅O₄

[ Molecular Weight ]:
307.31

[ Flash Point ]:
298.8±32.9 °C

[ Exact Mass ]:
307.128052

[ PSA ]:
117.54000

[ LogP ]:
1.15

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.797

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%