DNA2 inhibitor C5

Names

[ Name ]:
DNA2 inhibitor C5

[Synonym ]:
4-hydroxy-8-nitroquinolone-3-carboxylic acid
4-hydroxy-8-nitroquinoline-3-carboxylic acid
4-Hydroxy-8-nitro-chinolin-3-carbonsaeure

Biological Activity

[Description]:

DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 20 μM (DNA2 nuclease)[1]

[References]

[1]. Binghui Shen, et al. Dna2 inhibitors for cancer treatment. US20170226063A1.

Chemical & Physical Properties

[ Density]:
1.624g/cm3

[ Boiling Point ]:
437.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₆N₂O₅

[ Molecular Weight ]:
234.16500

[ Flash Point ]:
218.2ºC

[ Exact Mass ]:
234.02800

[ PSA ]:
116.24000

[ LogP ]:
2.07000

[ Index of Refraction ]:
1.674

Safety Information

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%