35973-25-2
35973-25-2 structure
- Name: DNA2 inhibitor C5
- Chemical Name: 8-nitro-4-oxo-1H-quinoline-3-carboxylic acid
- CAS Number: 35973-25-2
- Molecular Formula: C10H6N2O5
- Molecular Weight: 234.16500
- Catalog: Research Areas Cancer
- Create Date: 2016-11-20 15:50:25
- Modify Date: 2024-01-10 16:59:20
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DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1].
| Name | 8-nitro-4-oxo-1H-quinoline-3-carboxylic acid |
|---|---|
| Synonyms |
4-hydroxy-8-nitroquinolone-3-carboxylic acid
4-hydroxy-8-nitroquinoline-3-carboxylic acid 4-Hydroxy-8-nitro-chinolin-3-carbonsaeure |
| Description | DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1]. |
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| Related Catalog | |
| Target |
IC50: 20 μM (DNA2 nuclease)[1] |
| References |
[1]. Binghui Shen, et al. Dna2 inhibitors for cancer treatment. US20170226063A1. |
| Density | 1.624g/cm3 |
|---|---|
| Boiling Point | 437.2ºC at 760mmHg |
| Molecular Formula | C10H6N2O5 |
| Molecular Weight | 234.16500 |
| Flash Point | 218.2ºC |
| Exact Mass | 234.02800 |
| PSA | 116.24000 |
| LogP | 2.07000 |
| Index of Refraction | 1.674 |
| HS Code | 2933499090 |
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35973-25-2 |
| Literature: Pharmacia and Upjohn Company LLC Patent: EP1042295 B1, 2005 ; Location in patent: Page/Page column 59 ; |
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35973-25-2 |
| Literature: Riegel et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 1264 |
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35973-25-2 |
| Literature: Riegel et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 1264 |
| Precursor 3 | |
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| DownStream 0 | |
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |